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Osteogenesis Imperfecta
Drug Side Effects Article Links
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Osteogenesis
Imperfecta
of the jaw
Side Effects linked to jawbone death
.or
bone tumors. But about 10% were osteoporosis patients who had taken an
oral bisphosphonate, mainly Fosamax and Zometa. In May, Ruggiero ..Osteogenesis
imperfecta
of the jaw.
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Osteogenesis
Imperfecta
of the jaw
side effects causes Jaw Problems
...given
bisphosphonates intravenously. Some patients take oral bisphosphonates,
such as Fosamax and Zometa, for osteoporosis. The FDA acknowledges .Osteonecrosis
of the jaw..
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Jaw
Cancer
Side
Effects
Linked to Jaw Osteoporisis
..or
Zoledronate/Zoledronic Acid ( Zometa ) therapy for malignancy, but
several have occurred after oral treatment with Alendronate ( Fosamax, Zometa )
or Risedronate .osteogenesis imperfecta.. - Xagena.it
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Questions and Answers About Osteogenesis Imperfecta
Osteogenesis Imperfecta
What is osteogenesis imperfecta?
Osteogenesis imperfecta (OI), also known as brittle-bone disease, is a
genetic (inherited) disorder characterized by bones that break easily
without a specific cause. An estimated 20,000 to 50,000 people in the
US have this disease.
The disorder occurs in one out of 20,000 to one out of 60,000 live births. OI can affect males and females of all races.
What causes osteogenesis imperfecta?
The cause of OI is believed to be due to a genetic defect that causes
imperfectly-formed, or an inadequate amount of, bone collagen - a protein found in the connective tissue.
What are the types and symptoms of OI?
The following are the most common symptoms for osteogenesis imperfecta.
However, each individual may experience symptoms differently. Although
symptoms may vary, generally they are used to classify the four forms
of OI, each of which represents the severity of the condition.
According to the Osteoporosis and Related Bone Diseases National
Resource Center, part of the National Institutes of Health (NIH), the
types of OI and their symptoms include the following:
Type I:
- can usually be traced through the family
- near normal stature or slightly shorter
- blue sclera (the normally white area of the eye ball)
- hearing loss beginning in the early 20s and 30s
- most fractures occur before puberty; occasionally women will have fractures after menopause
- tendency toward spinal curvatures
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Type II:
- newborns severely affected; frequently fatal
- usually resulting from a new gene mutation
- very small stature with extremely small chest and under developed lungs
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Type III:
- tend to be isolated family incidents
- very small in stature - some only 3 feet tall
- fractures at birth very common
- x-ray may reveal healing of in utero fractures
- severe early hearing loss
- loose joints and poor muscle development in arms and legs
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Type IV:
- can frequently be traced through the family
- bones fracture easily - most before puberty
- normal or near normal colored sclera
- problems with teeth - more than Type I
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The symptoms of osteogenesis imperfecta may resemble other medical
conditions or problems. Always consult your physician for a diagnosis.
How is osteogenesis imperfecta diagnosed?
In addition to a complete medical history and physical examination,
diagnostic procedures for osteogenesis imperfecta may include a skin
biopsy to evaluate the amount and structure of collagen. However, this
test is complicated and not many qualified facilities are available to
perform the procedure. It is not unusual for results of the biopsy to
take up to six months.
Additional diagnostic tests may include:
- x-ray - a diagnostic test which uses invisible electromagnetic
energy beams to produce images of internal tissues, bones, and organs
onto film
- an examination of the ear, nose, and throat (to detect hearing loss)
Treatment for Osteogenesis Imperfecta
Specific treatment for osteogenesis imperfecta will be determined by your physician based on:
- your age, overall health, and medical history
- extent of the disease
- your tolerance for specific medications, procedures, or therapies
- expectations for the course of the disease
- your opinion or preference
To date, there is no known treatment, medicine, or surgery that
will cure osteogenesis imperfecta (OI). The goal of treatment is to
prevent deformities and fractures and allow the child to function as
independently as possible. Treatments for preventing or correcting
symptoms may include:
- care of fractures
- surgery
- rodding - a procedure to insert a metal bar the length of a long bone to stabilize it and prevent deformity
- dental procedures
- physical therapy
- assistive devices, such as wheelchairs, braces, and other custom-made equipment
Management of Osteogenesis Imperfecta (OI)
Management of the
disease includes focusing on preventing or minimizing deformities, and
maximizing the individual's functional ability at home and in the
community. Management of OI is either non-surgical or surgical.
Non-surgical interventions may include one or more of the following:
- physical therapy
- positioning aids (to help sit, lie, or stand)
- braces and splints (to prevent deformity and promote support or protection)
- medications
- psychological counseling
Surgical interventions may be considered to manage the following conditions:
- fractures
- bowing of bone
- scoliosis - a lateral, or sideways curvature and rotation of the
back bones (vertebrae), giving the appearance that the person is
leaning to one side.
- heart problems
Surgery may also be considered to maintain the ability to sit or stand. Long-Term Outlook for an Individual with Osteogenesis Imperfecta (OI)
Osteogenesis imperfecta (OI) is a progressive condition that needs
life-long management to prevent deformity and complications. The
interdisciplinary healthcare team helps the family to improve the
functional outcomes and to provide support. The Osteogenesis Imperfecta
Society can also be an important resource.
Osteonecrosis of the Jaw Information
Fosamax ( generic name - Alendronate
) is a type of drug known as bisphosphonates. Recently a link
has been found between bisphosphonates and a serious bone cancer disease called
osteonecrosis of the jaw ( ONJ ). This important discovery clearly
shows that Fosamax side effects may include
osteonecrosis of the jaw. The discovery, published in the Journal of Oral and
Maxillofacial Surgeons, prompted both the US, Food and Drug Administration (
FDA ) and Novartis, the manufacturer of bisphosphonates used in cancer
chemotherapy, to issue a warning to health care professionals on September 24,
2004. The warning letter contained information about jaw
cancer and bisphosphonates
and the risks of osteonecrosis in the jaw.
Bisphosphonates are commonly used in tablet form such
as Fosamax ( Alendronate Sodium ) to prevent and treat osteoporosis in
post-menopausal women. Stronger forms of bisphosphonates are commonly used in
the management of advanced cancers that have metastasized to the bone, where
the disease often causes bone pain and possibly even fractures. Several cancers
can involve or metastasize to the bone, including lung cancer, breast cancer,
prostate cancer, multiple myeloma,jaw cancer, and others. When bisphosphonates are given
in cancer chemotherapy, the drugs are given intravenously, and usually for
longer periods of time.
If you or a loved one have jaw
cancer and have been
injured as a result of Fosamax,Zometa, and Aredia side effects such as osteonecrosis of the jaw
contact today the offices of
Powell
Law Firm, L.C.
is the nation's leading law firm
for
litigation regarding Bisphosphonate Complications.
for your free,
confidential case evaluation
at toll-free 888-238-1998
Please state
your name and phone number
And we will
get back with you promptly
or email us
at
info@mpowelllaw.com
www.MPowellLaw.com Accepting Inquiries from the U.S.
and Internationally
Every case is different. No specific results are
implied.
269
South Beverly Drive, Suite 1156, Beverly Hills, CA 90212
.
.
Osteonecrosis of the Jaw
Jaw
Cancer
Osteonecrosis of the jaw ( ONJ ) is a condition in which the bone tissue in the
jaw fails to heal after minor trauma such as a tooth extraction, causing the
bone to be exposed. The exposure can eventually lead to infection and fracture
and may require long-term antibiotic therapy or surgery to remove the dying
bone tissue. Experts say that prevention and early treatment of individuals
using bisphosphonates such as Fosamax is extremely important in preserving the
jaw bone. Individuals using Fosomax or other bisphosphonates should attempt to
avoid tooth extractions and other major dental work while on the drugs.
Although most cases of osteonecrosis of the jaw related to Fosamax side effects
have occured after dental work several cases have been reported to occur
without any prior dental work. If you are currently taking Fosamax,Zometa, and
Aredia you may be
at risk of developing osteonecrosis. If you have been injured by Fosamax,Zometa,
and Aredia side
effects you may be entitled to compensation. For more information about your
legal rights contact the offices of
Powell
Law Firm, L.C.
is the nation's leading law firm
for
litigation regarding Bisphosphonate Complications.
for your free,
confidential case evaluation
at toll-free 888-238-1998
Please state
your name and phone number
And we will
get back with you promptly
or email us
at
info@mpowelllaw.com
www.MPowellLaw.com
Accepting Inquiries from the U.S.
and Internationally
Every case is different. No specific results are
implied.
269
South Beverly Drive, Suite 1156, Beverly Hills, CA 90212
Although most cases of osteonecrosis of the jaw related to Fosamax side effects
have occured after dental work several cases have been reported to occur
without any prior dental work. If you are currently taking Fosamax,Zometa, and
Aredia you may be
at risk of developing osteonecrosis. If you have been injured by Fosamax,Zometa,
and Aredia side
effects you may be entitled to compensation. For more information about your
legal rights contact the offices of
Powell
Law Firm, L.C.
is the nation's leading law firm
for
litigation regarding Bisphosphonate Complications.
for your free,
confidential case evaluation
at toll-free 888-238-1998
Please state
your name and phone number
And we will
get back with you promptly
or email us
at
info@mpowelllaw.com
www.MPowellLaw.com
Accepting Inquiries from the U.S.
and Internationally
Every case is different. No specific results are
implied.
269
South Beverly Drive, Suite 1156, Beverly Hills, CA 90212
Although most cases of osteonecrosis of the jaw related to Fosamax side effects
have occured after dental work several cases have been reported to occur
without any prior dental work. If you are currently taking Fosamax,Zometa, and
Aredia you may be
at risk of developing osteonecrosis. If you have been injured by Fosamax,Zometa,
and Aredia side
effects you may be entitled to compensation. For more information about your
legal rights contact the offices of
Powell
Law Firm, L.C.
is the nation's leading law firm
for
litigation regarding Bisphosphonate Complications.
for your free,
confidential case evaluation
at toll-free 888-238-1998
Please state
your name and phone number
And we will
get back with you promptly
or email us
at
info@mpowelllaw.com
www.MPowellLaw.com
Accepting Inquiries from the U.S.
and Internationally
Every case is different. No specific results are
implied.
269
South Beverly Drive, Suite 1156, Beverly Hills, CA 90212
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